NCT03093545

Effect of Rabies Immunoglobulin on Immunogenicity of Post-exposure Rabies Vaccination in Obese Patients

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: Mahidol University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

A single center, prospective cohort, open-label study of rabies post exposure program with equine rabies immunoglobulin (ERIG) and purified chick-embryo cell (PCEC) rabies vaccine in WHO category III exposed patients at Siriraj Hospital, Thailand aims to compare serum RVNA responses between obese (BMI \> 30 kg/m2) and normal weight/underweight (BMI \< 25 kg/m2) and to evaluate adverse events occurring after immunization on days 7, 14 and 28.

Detailed description

A single center, prospective cohort, open-label study of rabies post exposure program with equine rabies immunoglobulin (ERIG) and purified chick-embryo cell (PCEC) rabies vaccine in WHO category III exposed patients at Siriraj Hospital, Thailand aims to compare serum RVNA responses between obese (BMI \> 30 kg/m2) and normal weight/underweight (BMI \< 25 kg/m2) and to evaluate adverse events occurring after immunization on days 7, 14 and 28.

Conditions

• Rabies

Interventions

Type	Name	Description
BIOLOGICAL	Equine Rabies Immunoglobulin	40 IU per kg of body weight of ERIG at Day 0
BIOLOGICAL	Purified chick-embryo cell rabies vaccine	1 ml of PCEC Rabies vaccine on days 0, 3, 7, 14 and 28.

Timeline

• Start date: 2015-03-01
• Primary completion: 2016-10-01
• Completion: 2016-11-01
• First posted: 2017-03-28
• Last updated: 2017-04-04

Locations

1 site across 1 country: Thailand