NCT03092427

Probiotic Treatment in Juvenile Idiopathic Arthritis (JIA)

Evaluation of the Effectiveness of a Probiotic Treatment on Clinical Activity, Relapse Rates and Modification of the Intestinal Microbiota in Patients With Juvenile Idiopathic Arthritis (JIA)

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 51 (actual)
• Sponsor: Assistance Publique - Hôpitaux de Paris · Academic / Other
• Sex: All
• Age: 1 Year – 7 Years
• Healthy volunteers: Not accepted

Summary

This study investigates the efficacy of probiotic VSL#3 as an add on standard care on the activity of the disease in patients with Juvenile Idiopathic Arthritis.

Detailed description

Juvenile Idiopathic Arthritis (JIA) is the most frequent rheumatic disorder in children. Numerous studies suggest that alteration of the intestinal barrier may induce abnormal immune responses implicated in development or persistence of arthritis. This paves the way to new therapeutic options aiming to reestablish intestinal homeostasis to treat arthritis or to prevent disease flares. This study investigates the efficacy of probiotic VSL#3 as an add on standard care on the activity of the disease in patients with Juvenile Idiopathic Arthritis.

Conditions

• Juvenile Idiopathic Arthritis

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	VSL#3	Dietary Supplement
OTHER	Placebo	Placebo

Timeline

• Start date: 2017-09-04
• Primary completion: 2021-09-04
• Completion: 2022-09-04
• First posted: 2017-03-27
• Last updated: 2026-04-06

Locations

1 site across 1 country: France