NCT03084536

PECS Block vs. Multimodal Analgesia for Prevention of Persistent Postoperative Pain in Breast Surgery

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 134 (actual)
• Sponsor: Washington University School of Medicine · Academic / Other
• Sex: Female
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

In this double blinded randomized placebo-controlled trial, 160 subjects scheduled for breast surgery involving the axilla will be administered a multimodal pain regimen including acetaminophen, dexamethasone, celecoxib, and gabapentin. 80 subjects will also receive a Pectoral Nerve blocks I and II (PECS I and II block) preoperatively.

Conditions

• Breast Cancer
• Breast Cancer Female
• Cancer of Breast

Interventions

Type	Name	Description
DRUG	Bupivacaine	-Given after general anesthesia
DRUG	Gabapentin	* As per routine care * Will not be prescribed for any patient with preexisting kidney disease or ≥ 65 years.
DRUG	Celecoxib	* As per routine care * Will not be prescribed for any patient with preexisting kidney disease or ≥ 65 years. * Naproxen will be substituted for celecoxib in patients with sulfa allergies.
DRUG	Acetaminophen	-As per routine care
DRUG	Midazolam	-As per routine care
DRUG	Fentanyl	-As per routine care

Timeline

• Start date: 2017-06-07
• Primary completion: 2021-02-25
• Completion: 2021-02-25
• First posted: 2017-03-21
• Last updated: 2024-12-24
• Results posted: 2022-03-31

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study