NCT03083093

CTEPH Identification an Standard Computerised Tomography Pulmonary Angiography in Pulmonary Embolism Patients

Identification of CTEPH on Standard Computerised Tomography Pulmonary Angiography Performed in the Work-up of Suspected Pulmonary Embolism

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 100 (actual)
• Sponsor: Leiden University Medical Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: —

Summary

In this study the investigators will evaluate whether more careful reading (than the current standard) of routine computerised tomography pulmonary angiography (CTPA) performed in the clinical work-up of suspected (pulmonary embolism (PE) will differentiate patients with acute PE from those with more chronic or acute on chronic PE, which could be indicative of the presence of chronic thromboembolic pulmonary hypertension (CTEPH)"

Detailed description

The investigators will study 50 consecutive patients diagnosed with CTEPH as well as 50 patients diagnosed with acute PE in whom CTEPH was ruled out 2 years after the PE diagnosis by sequential echocardiography. The cases and controls will be matched based on the right-to-left ventrilcle diameter ratio. Three experienced thorax radiologists with specific expertise on acute PE and CTEPH will blindly assess the index CTPAs of the study population. In addition to the binominal judgement whether CTEPH signs are already present (or not), the presence of the following items will be scored by all 3 readers independently: * Webs or bands * Residual thrombus attached to the vascular wall * Complete occlusion /retraction * Mosaic perfusion * Pulmonary infarct * Parenchymal bands * Bronchial arteries * Right atrial (RA) dilatation * Right ventricle (RV) dilatation * Flattening of the septum * Right ventricle (RV) hypertrophy * Dilated truncus pulmonalis * Cardiac signs of pulmonary hypertension (PH) * Further remarks (free text)

Conditions

• CTEPH
• Pulmonary Embolism
• Early Diagnosis

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	The initial CTPA will be reviewed	The initial CTPA will be reviewed

Timeline

• Start date: 2017-05-01
• Primary completion: 2018-03-01
• Completion: 2018-03-01
• First posted: 2017-03-17
• Last updated: 2021-04-19
• Results posted: 2021-02-25

Locations

1 site across 1 country: Netherlands