NCT03081572

Platelet Function on Abacavir and Tenofovir

Differences in Platelet Function in Patients on Abacavir Versus Tenofovir Based Antiretroviral Regimens

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 24 (actual)
• Sponsor: University of California, Los Angeles · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This is a small observational study aimed at observing differences in platelet function in HIV patients on abacavir versus tenofovir based anti-HIV drugs. There is some correlation between platelet activation and cardiovascular disease- this study will act as a pilot to see if platelet activation among abacavir users may explain the correlation between abacavir and cardiovascular disease in HIV positive patients. This study will enroll 44 participants total; 22 on abacavir-based treatment, 22 on tenofovir-based treatment. There is only one study visit which includes a blood draw, physical assessment, and review of medical history.

Conditions

• Cardiovascular Diseases
• Platelet Aggregation, Spontaneous
• HIV/AIDS

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Platelet aggregation	Platelet aggregation

Timeline

• Start date: 2018-04-30
• Primary completion: 2020-02-15
• Completion: 2020-02-15
• First posted: 2017-03-16
• Last updated: 2020-11-19

Locations

1 site across 1 country: United States