NCT03076086

Investigation of Secreted Phosphoproteins and PiP3 (Phosphoinositolphospat 3) in Sputum

Investigation of Secreted Phosphoproteins and PiP3 (Phosphoinositolphospat 3) in Sputum Samples of Healthy Smokers and Non Smokers

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 21 (actual)
• Sponsor: Fraunhofer-Institute of Toxicology and Experimental Medicine · Academic / Other
• Sex: All
• Age: 25 Years – 45 Years
• Healthy volunteers: Accepted

Summary

The aim of this study is to validate two new biomarkers in sputum samples. These are PiP3 (phosphoinositolphospat ) and phosphor proteins, representing important proteins within inflammatory situations of the lung.

Detailed description

Within the study, sputum samples will be collected at 3 repetitive occasions in a 3 week interval of the different donors. The objective is to assess for biomarker specificity and reproducibility in the two groups (smokers and non-smokers). The methods for measurement shall be validated by repetitive measurement of the sputum samples, i.e. comparison of multiple measurements of the same sample and comparison of different samples from the same donor.

Conditions

• Healthy
• Smoking, Cigarette

Interventions

Type	Name	Description
OTHER	Induced sputum procedure	induced sputum is a sputum specimen produced for diagnostic tests by aerosol administration of a hypertonic saline solution.

Timeline

• Start date: 2017-05-12
• Primary completion: 2018-01-15
• Completion: 2018-01-15
• First posted: 2017-03-09
• Last updated: 2018-02-01

Locations

1 site across 1 country: Germany