NCT03076021

Effects of Isotretinoin on CYP2D6 Activity

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 33 (actual)
• Sponsor: University of Washington · Academic / Other
• Sex: All
• Age: 12 Years
• Healthy volunteers: Not accepted

Summary

Specific Aim: To investigate if isotretinoin (13-cis-retinoic acid) administration decreases CYP2D6 activity in adolescent patients.

Detailed description

In this aim, we will conduct a drug-drug interaction study evaluating the effects of 13-cis-retinoic acid on non-induced CYP2D6 activity in adolescent patients. Secondary analysis will evaluate the relationship between retinoid concentrations and CYP2D6 activity in these special populations

Conditions

• CYP2D6 Polymorphism

Interventions

Type	Name	Description
DRUG	Isotretinoin	Drug interaction study
DRUG	dextromethorphan	Drug interaction study

Timeline

• Start date: 2016-07-26
• Primary completion: 2023-11-27
• Completion: 2023-11-27
• First posted: 2017-03-09
• Last updated: 2025-01-28
• Results posted: 2025-01-28

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study