NCT03075163

Post-Operative Therapy for Nausea or Vomiting

Optimization of Post-Operative Therapy for Nausea or Vomiting

• Status: Terminated
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 300 (actual)
• Sponsor: University of California, Davis · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This is a single site, prospective, randomized controlled study designed to evaluate the impact of acupressure when used as an initial treatment before rescue medications in the treatment of post-operative nausea and/or vomiting at UCD.

Detailed description

Each individual will only participate in the post anesthetic care unit starting from when the patient's nurse or anesthesiology team deems that the patient needs treatment for PONV. It ends when the patient is discharged from anesthesiology care. Patients will be asked to score nausea before randomized treatment of acupressure or medication, and to score nausea after treatment.

Conditions

• Vomiting
• Nausea

Interventions

Type	Name	Description
PROCEDURE	Acupressure	Specifically trained personnel will apply pressure on the wrists bilaterally at the P6 point for up to 3 minutes. The P6 point is located three fingerbreadths from the wrist crease on the volar surface of the arm between the palmaris longus and flexor carpi radialis. In the event of failure in the acupressure group, further treatments will be identical to the control group. Since Ondansetron is the standard Post Anesthetic Care Unit treatment, it will be first line rescue therapy except in the case that the patient has received 8mg in the past 6 hours. If needed, further antiemetic pharmacologic treatments may include, but are not limited to, phenergan, metoclopramide, haloperidol, diphenhydramine or propofol at the clinical discretion of the patient's anesthesiology care team.
DRUG	Ondansetron	Ondansetron is a medication that belongs to the drug class known as antiemetic and selective 5-HT3 receptor antagonist. Ondansetron is prescribed for the treatment of nausea and vomiting due to cancer chemotherapy and also used to prevent and treat nausea and vomiting after surgery.

Timeline

• Start date: 2016-10-18
• Primary completion: 2017-04-01
• Completion: 2018-12-01
• First posted: 2017-03-09
• Last updated: 2019-06-18
• Results posted: 2019-06-04

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study