Trials / Completed
CompletedNCT03070197
Genomic Basis of Neurodevelopmental and Brain Outcomes in Congenital Heart Disease (CHD Brain and Genes)
Genomic Basis of Neurodevelopmental and Brain Outcomes in Congenital Heart Disease
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 196 (actual)
- Sponsor
- Children's Hospital Medical Center, Cincinnati · Academic / Other
- Sex
- All
- Age
- 8 Years
- Healthy volunteers
- Not accepted
Summary
Approximately 400 Congenital heart disease patients will participate in the research study which will include one or more research visits for neurodevelopmental testing, brain MRI, and collection of medical history including previously collected genetic sequencing results. The investigators will explore the association between genetic variants, neurodevelopmental deficits, and brain MRI endophenotype. Analyses will compare groups with and without deleterious de novo mutations.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | Exposure of interest: Brain MRI | Brain MRI will be conducted in all participants |
| OTHER | Exposure of interest: neurodevelopmental assessments | neurodevelopmental testing will be conducted in all participants. |
Timeline
- Start date
- 2017-09-18
- Primary completion
- 2020-06-29
- Completion
- 2020-06-29
- First posted
- 2017-03-03
- Last updated
- 2020-08-13
Locations
8 sites across 1 country: United States
Source: ClinicalTrials.gov record NCT03070197. Inclusion in this directory is not an endorsement.