NCT03069300

N-ACetylcysteine to Reduce Infection and Mortality for Alcoholic Hepatitis

The Mechanism of Action of N-acetylcysteine for Reducing the Risk of Infection in Alcoholic Hepatitis

• Status: Unknown
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 42 (estimated)
• Sponsor: Imperial College London · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Recent data have suggested that monocyte oxidative burst defect is associated with the development of infection in patients with severe alcoholic hepatitis. One report found reduced 28 day mortality in patients treated with N-acetylcysteine combined with prednisolone when compared to prednisolone alone. The current study seeks to reveal whether the mechanism by which NAC reduces susceptibility to infection is through improvement of phagocyte oxidative burst.

Detailed description

Randomised controlled trial, open label.

Conditions

• Alcoholic Hepatitis
• Infection

Interventions

Type	Name	Description
DRUG	N-acetyl cysteine (NAC)

Timeline

• Start date: 2015-10-01
• Primary completion: 2022-04-01
• Completion: 2025-06-01
• First posted: 2017-03-03
• Last updated: 2021-11-09

Locations

1 site across 1 country: United Kingdom