Trials / Unknown
UnknownNCT03059225
rTMS in Aphasic Patients With Neuroimage Assessments
Synchronous rTMS and Computer-integrated Speech Training Applied in Aphasic Patients
- Status
- Unknown
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 120 (estimated)
- Sponsor
- Taipei Veterans General Hospital, Taiwan · Other Government
- Sex
- All
- Age
- 30 Years – 85 Years
- Healthy volunteers
- Not accepted
Summary
The refinement of repetitive transcranial magnetic stimulation (rTMS) has highlighted its merit in terms of learning programs as a treatment for aftereffect augmentation. Nevertheless, the efficacy of synchronous rTMS protocol integrated with computer-integrated speech training is not well understood. It is also not clear regarding the efficacy of compound bi-hemispheric stimulation protocol. The aim of the study is to investigate language response to these new strategies and to determine the longevity of the therapeutic outcome. Advanced MR neuroimaging techniques, such as fMRI and DTI, are powerful tools to evaluate the concomitant nervous changes after rTMS treatment on aphasic patients. The knowledge from fMRI and DTI microstructural evolution provides insight into underlined mechanism operating the language improvement.
Detailed description
The efficacy of synchronous rTMS protocol integrated with computer-integrated speech training is not well understood. It is also not clear regarding the efficacy of inhibitory or excitatory stimulation protocol. The aim of the study is to investigate language response to these new strategies and to determine the longevity of the therapeutic outcome. Advanced MR neuroimaging techniques, such as fMRI and DTI, are powerful tools to evaluate the concomitant nervous changes after rTMS treatment on aphasic patients. The knowledge from fMRI and DTI microstructural evolution provides insight into underlined mechanism operating the language improvement
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DEVICE | repetitive transcranial magnetic stimulation (rTMS) | undergo contralesional 1Hz repetitive transcranial magnetic stimulation(rTMS) or high frequency ipsilesional rTMS for 10 daily sessions |
| DEVICE | Sham stimulation | 2-week inhibitory non-dominate hemisphere rTMS program |
Timeline
- Start date
- 2017-02-18
- Primary completion
- 2021-12-23
- Completion
- 2021-12-23
- First posted
- 2017-02-23
- Last updated
- 2021-01-08
Locations
1 site across 1 country: Taiwan
Source: ClinicalTrials.gov record NCT03059225. Inclusion in this directory is not an endorsement.