NCT03057171

A Study on the Gastrointestinal Disease and Helicobacter Pylori Controlled Long Non-coding RNA

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 50 (estimated)
• Sponsor: Yonsei University · Academic / Other
• Sex: All
• Age: 19 Years
• Healthy volunteers: Accepted

Summary

Helicobacter pylori (H.pylori) is a major human pathogenic bacterium in gastric mucosa which is linked to the development of gastritis, peptic ulcer disease, mucosa-associated lymphoid tissue lymphoma and gastric cancer. However the regulatory mechanism of H.pylori-induced immune response is not clear. Long non-coding RNA (lncRNA) has recently emerged as key post-transcriptional regulators of gene expression, differentiation. The investigators had a preliminary results which THRIL (TNFα and hnRNPL related immunoregulatory lincRNA) and PACER(p50-associated COX-2 extragenic RNA) played a potential role in H.pylori induced inflammatory cascade. However, there wasn't a previous study about expression of THRIL, PACER in a human tissue. Therefore, the investigators aimed to evaluate the expression of THRIL, PACER in patients with gastrointestinal disease according to H.pylori infection.

Conditions

• Helicobacter Pylori Infection
• Gastric Ulcer
• Duodenal Ulcer
• Stomach Cancer

Timeline

• Start date: 2015-05-01
• Primary completion: 2020-04-01
• Completion: 2020-04-01
• First posted: 2017-02-17
• Last updated: 2019-03-18

Locations

1 site across 1 country: South Korea