NCT03056547

Biomarkers in Dyspnea

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 34 (actual)
• Sponsor: Association pour le Développement et l'Organisation de la Recherche en Pneumologie et sur le Sommeil · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

To explore biological mechanisms in human model of induced dyspnea, in order to remove the source of dyspnoea, to modify cerebral impact and to allow the development of targeted therapies.

Detailed description

The aim of the study will be to identify a specific biology and immunology associated with dyspnoea. It will open therapeutic possibilities through a better understanding of the mechanisms of dyspnea. Healthy volunteers will underwent two types of dyspnea. The subjects will be first familiar with both types of dyspnea and dyspnea measurement scales. Different components of dyspnea will be measured. Blood tests will be performed at different times (before dyspnea, during dyspnea, 60 and 90 min after dyspnea)

Conditions

• Healthy Volunteers

Interventions

Type	Name	Description
OTHER	Induced dyspnea	Biological samples will be assessed during and after breathing discomfort induced by laboratory models of dyspnea ("work/effort", "air hunger").

Timeline

• Start date: 2017-11-23
• Primary completion: 2019-01-08
• Completion: 2019-01-08
• First posted: 2017-02-17
• Last updated: 2019-09-13

Locations

1 site across 1 country: France