NCT03055260

Low Intensity Blood Flow Restriction Training Study

Effect of Low Intensity Blood Flow Restriction Training on Lower Extremity Strength and Hypertrophy

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 8 (actual)
• Sponsor: University of Minnesota · Academic / Other
• Sex: All
• Age: 18 Years – 49 Years
• Healthy volunteers: Accepted

Summary

The particpant will complete baseline testing by measuring subjects' quadriceps muscle thickness (cm) via ultrasound technology, as well as have them complete a one repetition maximum (1RM) test on the leg press machine and an isometric knee extension using a dynamometer - strength measures will be calculated for both right and left legs. After baseline testing, subjects will complete 6 weeks of the testing protocol that will consist of leg press exercises at 30% of their 1RM. Subjects will be randomized to either wear a cuff that partially restricts blood flow to the limb (Study Group), or to wear a cuff that does not restrict blood flow (Control Group). Exercises will be completed 2x/week and will take approximately 10 total minutes (5 for warm up, 5 for testing protocol) per session. After 6 weeks, muscle thickness, leg press 1RM, and quadriceps extension strength will be re-tested and compared to the initial measurements.

Detailed description

Session 1 - baseline testing * 5-minute warm-up; 1RM calculation for both right and left legs using a supine leg press machine; isometric quadriceps strength measurement using a dynamometer; muscle thickness measurements of both right and left quadriceps muscle using ultrasound technology. * After day 1 testing; randomly allocate subjects to either control group or experimental group Sessions 2-13 - 6 weeks of exercise protocol, 2x/per week Both the experimental and control groups will complete the same protocol for the entirety of the study: * 5- minute warm up * Using a single-leg press exercise machine: Subjects complete the testing protocol with either partial blood flow restriction (cuff inflated to 100-250 mmhg depending on size of person) or no blood flow restriction (placebo inflation) on right limb. * Protocol: 30 repetitions - 15 repetitions - 15 repetitions - 15 repetitions with each set separated by \~30-90 seconds. * Right and left legs will be alternating, but only one leg will have the occlusion cuff Session 14 - Re-test \- Re-check 1RM, isometric quad strength, as well as muscle thickness of quadriceps with ultrasound

Conditions

• Muscle Mass

Interventions

Type	Name	Description
DEVICE	Blood flow restriction cuff	The intervention is the wearing of a cuff-like band around the affected limb, of which partially restricts blood flow to the limb.
DEVICE	Blood Flow restriction Cuff-Placebo	The intervention is the wearing of a cuff-like band around the affected limb, of which partially restricts blood flow to the limb.

Timeline

• Start date: 2017-05-23
• Primary completion: 2018-12-31
• Completion: 2018-12-31
• First posted: 2017-02-16
• Last updated: 2020-02-28
• Results posted: 2020-02-28

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated device study