NCT03054779

Canola Oil Multi-center Intervention Trial II

Canola Oil Multi-center Intervention Trial II (COMIT II): Effects of Oleic Acid Enriched and Regular Canola Oil on Body Composition and Lipid Metabolism in Participants With Metabolic Syndrome Risk Factors

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 28 (actual)
• Sponsor: Penn State University · Academic / Other
• Sex: All
• Age: 20 Years – 65 Years
• Healthy volunteers: Accepted

Summary

Building on the findings from the investigators previous study, COMIT I, the purpose of the COMIT II study is to supplement the DEXA measurement of body composition with a supplementary DEXA measurement of visceral adipose tissue and to specifically target the impact of oleic acid consumption on body composition as the primary objective. COMIT II also will include analysis of fatty acid ethanolamines (FAEs) and their precursors to elucidate the mechanisms by which canola oil may be modifying body composition, measurement of endothelial function, inflammatory, adiposity and insulin sensitivity biomarkers, and genetic analyses.

Conditions

• Cardiovascular Disease
• Metabolic Syndrome

Interventions

Type	Name	Description
OTHER	Canola Oil	Regular canola oil will be iso-calorically incorporated into fruit smoothies made with milk and consumed twice daily.
OTHER	High oleic acid canola oil	High oleic acid canola oil will be iso-calorically incorporated into fruit smoothies made with milk and consumed twice daily.
OTHER	Western diet oil combination	A typical "Western diet" fat intake as a control treatment, comprised of 11% MUFA, 11% PUFA (9% omega-6 fatty acids and 2% omega-3 fatty acids), and 13% SFA, will be iso-calorically incorporated into fruit smoothies made with milk and consumed twice daily

Timeline

• Start date: 2014-09-01
• Primary completion: 2016-11-01
• Completion: 2016-11-01
• First posted: 2017-02-16
• Last updated: 2023-08-21

Locations

1 site across 1 country: United States