NCT03054584

Genetic Basis of Melanocytic Nevi

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 50 (estimated)
• Sponsor: University of California, Davis · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The objective of this protocol is to further elucidate the genetic mutations that drive melanocytic nevi (benign melanocytic neoplasms, moles). This will be performed by whole genome, whole exome, or targeted sequencing of de-identified specimens. Herein, the investigators plan to isolate DNA from de-identified skin biopsy specimens and blood samples: 1. From melanocytic nevi collected by skin biopsy (a shave or punch biopsy). A part of the tissue will be submitted for routine diagnostic dermatopathology and investigational histomorphologic and immunohistochemical analysis. 2. From corresponding normal tissue (blood). DNA isolated from blood will be used as a normal control when analyzing sequencing data to identify somatic mutations in lesional tissue.

Conditions

• Melanocytic Nevi

Interventions

Type	Name	Description
OTHER	Collecting Nevi	Will be collecting Nevi and completing a DNA analysis, no intervention will be made.

Timeline

• Start date: 2017-06-26
• Primary completion: 2028-06-01
• Completion: 2028-06-01
• First posted: 2017-02-15
• Last updated: 2025-09-18

Locations

1 site across 1 country: United States