NCT03053960

Helical CT, PET/CT, MRI, and CBCT Alone or in Combination in Predicting Jaw Invasion in Patients With Oral Cancer

Predictability of Carcinomatous Invasion of the Maxilla or Mandible: An Assessment of Radiologic Modalities With Histologic Correlation

• Status: Terminated
• Phase: —
• Study type: Observational
• Enrollment: 8 (actual)
• Sponsor: Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

This clinical trial studies how well helical computed tomography (CT), positron emission tomography (PET)/CT, magnetic resonance imaging (MRI), and cone beam computed tomography (CBCT) work alone or in combination in predicting whether tumor cells have spread to the jaw bone (jaw invasion) in patients with oral cancer. Imaging, such as helical CT, PET/CT, MRI, and CBCT, may help find out how far cancer has spread. Accurate prediction of the presence or absence of jaw invasion may help create a better surgical treatment plan for patients with oral cancer.

Detailed description

PRIMARY OBJECTIVES: I. To determine which imaging modality or combination of imaging methods, in conjunction with clinical and histological examination, will most accurately predict the presence or absence of invasion of the mandible or maxilla by intraoral squamous cell carcinoma (SCC). SECONDARY OBJECTIVES: I. To compare the histopathologic findings to the radiologic findings.

Conditions

• Oral Cavity Squamous Cell Carcinoma

Interventions

Type	Name	Description
DEVICE	Computed Tomography	Undergo helical CT scan
DEVICE	Positron Emission Tomography and Computed Tomography Scan	Undergo PET/CT scan
DEVICE	Cone-Beam Computed Tomography	Undergo CBCT scan
DEVICE	Magnetic Resonance Imaging	Undergo MRI scan
PROCEDURE	Therapeutic Conventional Surgery	Undergo resection of tumor
PROCEDURE	Histopathologic Examination	Correlative studies

Timeline

• Start date: 2015-11-24
• Primary completion: 2018-11-01
• Completion: 2018-11-01
• First posted: 2017-02-15
• Last updated: 2025-04-30
• Results posted: 2019-12-18