NCT03052595

Multiple Sclerosis: The Role of Mitochondrial Dysfunction in IR Resistance

Multiple Sclerosis: The Role of Mitochondrial Dysfunction in Insulin Resistance

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 70 (actual)
• Sponsor: Slovak Academy of Sciences · Other Government
• Sex: All
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS) and is one of the most common neurological diseases, often leading to disability of the patients. The MS pathogenesis includes vascular and inflammatory components, however recently also the role of mitochondrial dysfunction being a hot topic in neurodegeneration.

Detailed description

Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS) and is one of the most common neurological diseases, often leading to disability of the patients. The MS pathogenesis includes vascular and inflammatory components, however recently also the role of mitochondrial dysfunction being a hot topic in neurodegeneration. Current project is based on previous project results, where the investigators of this project found signs of insulin resistance (IR) with hyperinsulinemia in patients with MS, which seem not to be related to chronic inflammation or low physical activity. Therefore aim of the present project is to elucidate impact of mitochondrial dysfunction in the pathogenesis of impaired insulin action and its role in the neurodegenerative process. To test the hypothesis, mitochondrial function, endothelial function, changes in membrane proteins and function of autonomic nervous system will be assessed. Those parameters will be measured non-invasively and in samples of blood, cerebrospinal fluid and skeletal muscle. MS patients will be examined at the time of diagnosis and after 12 months of treatment; healthy subjects will be used as controls. Elucidation of insulin resistance cause and the role of mitochondrial dysfunction in pathogenesis of disease is expected. Potential outcome of the project could be the answer, if pharmacological or non-pharmacological intervention might lead to improvement of mitochondrial function and therefore represent a new approach to prevent MS progression.

Conditions

• Multiple Sclerosis
• Mitochondrial Alteration

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Oral glucose tolerance test	Oral glucose tolerance test to measure glucose and insulin concentrations after oral glucose load
DIAGNOSTIC_TEST	Testing of autonomous nervous system function	Autonomous nervous system function will be assessed using a battery of tests (orthostasis, Valsalva manoeuvre, heart rate variability recording, blood hormone levels, ect.)
DIAGNOSTIC_TEST	Stroop test	Stroop test will be used to test cognitive function

Timeline

• Start date: 2017-02-01
• Primary completion: 2023-03-31
• Completion: 2023-03-31
• First posted: 2017-02-14
• Last updated: 2023-04-12

Locations

1 site across 1 country: Slovakia