Trials / Completed
CompletedNCT03050593
Developing Imaging And plasMa biOmarkers iN Describing Heart Failure With Preserved Ejection Fraction (DIAMONDHFpEF)
Prospective, Observational, Single-centre, Cohort Study Aimed at Developing Imaging and Plasma Biomarkers in Heart Failure With Preserved Ejection Fraction
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 280 (actual)
- Sponsor
- University of Leicester · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Accepted
Summary
The investigators wish to test a hypothesis that patients with HFpEF have different characteristics on echo, cardiac MRI and plasma protein \& chemical profiles compared to HFrEF and healthy volunteers.
Detailed description
Large scale prospective studies incorporating cardiac MRI, echocardiography and plasma sampling are currently lacking in HFpEF. The main aims of our study are to: 1. better phenotype and characterise HFpEF (also comparing with HFrEF and age- and sex- matched healthy controls) 2. provide mechanistic insights into pathophysiology 3. describe potential biomarkers and their relation to relevant clinical outcomes (exercise capacity, heart failure quality of life and prognosis)
Conditions
- Patients With Heart Failure and Preserved Ejection Fraction - HFpEF
- Patients With Heart Failure With Reduced Ejection Fraction - HFrEF
- Healthy Controls Group - Age and Sex-matched
Interventions
| Type | Name | Description |
|---|---|---|
| DIAGNOSTIC_TEST | MRI scan, Echo scan |
Timeline
- Start date
- 2013-02-01
- Primary completion
- 2015-05-01
- Completion
- 2015-05-01
- First posted
- 2017-02-13
- Last updated
- 2017-02-13
Source: ClinicalTrials.gov record NCT03050593. Inclusion in this directory is not an endorsement.