NCT03049358

Olfactory Training in Improving Sense of Smell After Radiation Therapy in Patients With Paranasal Sinus or Nasopharyngeal Cancer

Olfactory Training For Post Radiation Olfactory Loss In Patients With Paranasal Sinus and Nasopharyngeal Carcinoma

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 15 (actual)
• Sponsor: Stanford University · Academic / Other
• Sex: All
• Age: 19 Years
• Healthy volunteers: Not accepted

Summary

This randomized phase I trial studies how well olfactory training works in improving sense of smell after radiation therapy in patients with paranasal sinus or nasopharyngeal cancer. Olfactory training may improve smell function after radiation therapy in patients with paranasal sinus or nasopharyngeal cancer.

Detailed description

PRIMARY OBJECTIVES: I. To evaluate the effect of olfactory training on olfactory function in patients with paranasal sinus and nasopharyngeal carcinoma suffering from olfactory loss after radiation. SECONDARY OBJECTIVES: I. To evaluate the possible effect of olfactory training on quality of life in patients with paranasal sinus and nasopharyngeal carcinoma suffering from olfactory loss after radiation. II. To study rate and severity of olfactory dysfunction after radiation therapy in patients with paranasal sinus or nasopharyngeal carcinoma. III. To evaluate the possible preventive effect of olfactory training on olfactory dysfunction in patients with paranasal sinus and nasopharyngeal carcinoma who will undergo radiation therapy. OUTLINE: Patients are randomized to 1 of 2 arms. Arm I: Patients undergo olfactory training by smelling 4 essential oils in vials (rose, lemon, clove, and eucalyptus) over 15 seconds each, twice daily for 12 weeks. Arm II: Patients undergo sham training by smelling canola oil in 4 vials over 15 seconds each, twice daily for 12 weeks.

Conditions

• Stage 0 Nasopharyngeal Carcinoma
• Stage 0 Paranasal Sinus Cancer
• Stage I Nasopharyngeal Carcinoma
• Stage I Paranasal Sinus Cancer
• Stage II Nasopharyngeal Carcinoma
• Stage II Paranasal Sinus Cancer
• Stage IIA Nasopharyngeal Carcinoma
• Stage IIB Nasopharyngeal Carcinoma
• Stage III Nasopharyngeal Carcinoma
• Stage III Paranasal Sinus Cancer
• Stage IV Nasopharyngeal Carcinoma
• Stage IV Paranasal Sinus Cancer
• Stage IVA Nasopharyngeal Carcinoma
• Stage IVA Paranasal Sinus Cancer
• Stage IVB Nasopharyngeal Carcinoma
• Stage IVB Paranasal Sinus Cancer
• Stage IVC Nasopharyngeal Carcinoma
• Stage IVC Paranasal Sinus Cancer

Interventions

Type	Name	Description
OTHER	Physiologic Testing	Undergo UPSIT smell test
OTHER	Quality-of-Life Assessment	Ancillary studies
PROCEDURE	Sham Intervention	Undergo sham training
PROCEDURE	Therapeutic Procedure	Undergo olfactory training
OTHER	rose essential oil	patient smells rose oil in vial
OTHER	lemon essential oil	patient smells lemon oil in vial
OTHER	clove essential oil	patient smells clove oil in vial
OTHER	eucalyptus essential oil	patient smells eucalyptus oil in vial
OTHER	canola oil placebo	patient smells canola oil in vial

Timeline

• Start date: 2016-12-01
• Primary completion: 2018-10-01
• Completion: 2018-10-01
• First posted: 2017-02-10
• Last updated: 2019-02-05

Locations

1 site across 1 country: United States