NCT03048240

INtraoperative photoDYnamic Therapy of GliOblastoma

A Pilot Study of the Feasibility of Intraoperative Photodynamic Therapy of Glioblastoma.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 10 (actual)
• Sponsor: University Hospital, Lille · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The study pilot evaluate the feasibility of a "5-ALA- PpIX (protoporhyrin IX) mediated per-PDT protocol" in patients with glioblastoma accessible for complete surgical removal of contrast. This treatment will be carried out in addition to the current reference treatment of glioblastoma: maximum resection surgery followed by radiochemotherapy according to the protocol Stupp

Conditions

• Glioblastoma

Interventions

Type	Name	Description
DEVICE	"perPDT"	The protocol requires the realization of specific procedures in addition to the usual care. The per-operative photodynamic therapy ("perPDT") added to surgery for glioblastoma excision. The patient will receive 5-ALA (5- alanine ,GLIOLAN drinkable) 4h before surgery + lighting of the tumor bed by a light source (laser) at the end of resection (Prolonged surgery of 45 minutes).
DRUG	GLIOLAN	patient will receive 5-ALA (5- alanine ,GLIOLAN drinkable) 4h before surgery

Timeline

• Start date: 2017-05-05
• Primary completion: 2021-04-28
• Completion: 2021-04-28
• First posted: 2017-02-09
• Last updated: 2026-02-05

Locations

1 site across 1 country: France