NCT03046186

Physiological Effects of Gastric Sleeve Operation

Effect of Gastric Sleeve Operation on Absorption and Metabolism of Glucose and Protein as Well as Gut-hormonal Response - A Comparison With Roux-en-Y Gastric Bypass

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 36 (actual)
• Sponsor: Hvidovre University Hospital · Academic / Other
• Sex: All
• Age: 25 Years – 60 Years
• Healthy volunteers: Accepted

Summary

After gastric sleeve patients undergo a substantial weight loss, but the physiological mechanisms behind the weight loss is not fully elucidated. Studies suggest that gut-hormone secretion is altered comparable to what is also seen after Roux-en-Y gastric bypass, however to which extent is not fully established and furthermore, the mechanisms behind an altered secretion are unclear. The purpose of this study is to investigate absorption and postprandial metabolism of glucose and protein in addition to gut hormonal responses after gastric sleeve compared with a group of un-operated subjects machted on sex, age and BMI. Furter, a group of Roux-en-Y gastric bypass operated patients matched on pre-operative BMI, current BMI, sex and age will be included for comparison.

Conditions

• Obesity, Morbid
• Bariatric Surgery

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Mixed meal test with double tracer technique

Timeline

• Start date: 2016-06-01
• Primary completion: 2017-06-01
• Completion: 2017-06-01
• First posted: 2017-02-08
• Last updated: 2020-11-30

Locations

1 site across 1 country: Denmark