NCT03046043

AF Ablation Based on High Density Voltage Mapping and CFAE

Ablation of Persistent Atrial Fibrillation Based on High Density Voltage Mapping and Complex Fractionated Atrial Electrogram

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 50 (actual)
• Sponsor: Keimyung University Dongsan Medical Center · Academic / Other
• Sex: All
• Age: 20 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to evaluate the efficacy of additional ablation targeting complex fractionated atrial electrogram area within low voltage zone identified by high resolution mapping in patients with persistent atrial fibrillation.

Detailed description

Fifty patients with persistent atrial fibrillation will be randomized a 1:1 ratio to each group. A test group includes those who undergoing ablation targeting low voltage areas which contains complex fractionated trial electrogram in addition to pulmonary vein isolation and a control group includes who undergoing pulmonary vein isolation only.

Conditions

• Atrial Fibrillation

Interventions

Type	Name	Description
PROCEDURE	pulmonary vein isolation	pulmonary vein isolation is conducted on the junction between the left atrium and pulmonary vein
PROCEDURE	Low-Voltage & CFAE guided ablation	In CFAE guided ablation,. Within low voltage zone, CFAE areas defined by shortest SCI and high ICL are identified.-Areas with the shortest SCI and high ICL within low voltage areas should be targeted first, followed by longer SCI regions (up to 120ms). Radiofrequency energy is delivered at target sites for 30-60 sec until the local electrogram is completely eliminated.

Timeline

• Start date: 2017-10-01
• Primary completion: 2019-11-30
• Completion: 2019-12-23
• First posted: 2017-02-08
• Last updated: 2020-02-21

Locations

1 site across 1 country: South Korea