NCT03043924

Functional Study of the Hypothalamus in Magnetic Resonance Imaging (MRI) in Polycystic Ovary Syndrome (PCOS)

Functional Study of the Hypothalamus in High-resolution Magnetic Resonance Imaging (MRI) in Women With Polycystic Ovary Syndrome (PCOS): a Comparative Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 52 (actual)
• Sponsor: University Hospital, Lille · Academic / Other
• Sex: Female
• Age: 19 Years – 30 Years
• Healthy volunteers: Accepted

Summary

The aim to evaluate whether activation of the hypothalamic-pituitary-gonadal axis in PCOS is associated with transient microstructural and metabolic changes in the female hypothalamus using MRI approaches to assess water diffusion and measure proton magnetic resonance spectra.

Conditions

• Polycystic Ovary Syndrome

Interventions

Type	Name	Description
DRUG	Cyproterone Acetate + estradiol	PCOS will receive: 50mg cyproterone acetate (Androcur®) in combination with p.o. 2mg estradiol daily
DRUG	Levonorgestrel, Ethinyl Estradiol 0.1-0.02Mg Oral Tablet	Healthy volunteers receive combined oral contraceptive (COC) consisting 0.02 mg ethinylestradiol and 0.1mg of progestins (Leeloo Gé®)

Timeline

• Start date: 2017-09-26
• Primary completion: 2022-04-15
• Completion: 2022-04-15
• First posted: 2017-02-06
• Last updated: 2025-12-11

Locations

1 site across 1 country: France