NCT03043157

Rocuronium Effective Dose for Laparoscopic Cholecystectomy

Rocuronium ED50 for Excellent Laparoscopic Conditions for Cholecistectomy: Dose-finding Adaptative Clinical Trial

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: Brasilia University Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

This is an adaptative study where each participant's rocuronium dose will depend on the previous patient's response, being higher if it was not enough and lower if it was more than enough.

Detailed description

Rocuronium is one of the most used neuromuscular blockers to help intubation and to relax abdominal wall for laparoscopic surgery. Rocuronium intubation dose can be enough for intubation but not last enough for excellent laparoscopic conditions. There is little variation in time from anesthesia induction to the end of the laparoscopy for cholecystectomy and avoiding excess rocuronium dose can help providing excellent conditions and fast track extubation. Dixon's up-and-down method will guide this dose-finding study for the ED50.

Conditions

• Muscle Relaxation

Interventions

Type	Name	Description
DRUG	rocuronium	intravenous rocuronium infusion

Timeline

• Start date: 2017-02-15
• Primary completion: 2017-03-02
• Completion: 2017-03-02
• First posted: 2017-02-03
• Last updated: 2017-09-13

Locations

1 site across 1 country: Brazil