NCT03043144

Taste And Smell TEsting in End Stage Renal Disease

TASTE ESRD: Taste And Smell TEsting in End Stage Renal Disease

• Status: Withdrawn
• Phase: —
• Study type: Observational
• Enrollment: 0 (actual)
• Sponsor: Beth Israel Deaconess Medical Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Malnutrition is an important complication of advanced kidney disease and impairment in smell and taste may affect nutritional status. This study will examine the association between impairment in smell and taste and nutritional and functional markers among patients with end stage renal disease, as well as risk factors for smell and taste impairment.

Detailed description

People with advanced chronic kidney disease (CKD) are at risk for malnutrition, which is associated with significantly increased mortality. Impairments in olfaction and taste are under-recognized and under-addressed symptoms that affect this population. Olfaction and taste influence appetite and nutritional status and represent a unique target for study and intervention. Small cross-sectional studies have shown a higher prevalence of olfactory (up to 56%) and taste disturbances (up to 35%) among patients with CKD compared with the general population, but little is known about longitudinal change in olfaction and taste in this population. Additionally, there is a lack of understanding about why these sensory disturbances more commonly occur in people with CKD, although there is speculation that uremia may contribute. This information gained from this study will address these gaps in knowledge by studying longitudinal changes in olfaction and taste and their associations with concurrent and future nutritional and functional status. Additionally this study will attempt to identify potentially modifiable risk factors associated with olfactory and taste impairment.

Conditions

• Kidney Failure, Chronic
• Olfaction Disorders
• Taste Disorders
• Malnutrition

Interventions

Type	Name	Description
OTHER	Worsening of olfaction from enrollment visit to 6 months	Worsening of olfaction from enrollment visit to 6 months will be evaluated for association with the primary and secondary outcomes
OTHER	Worsening of taste from enrollment visit to 6 months	Worsening of taste from enrollment visit to 6 months will be evaluated for association with the primary and secondary outcomes
OTHER	Serum Zinc	Serum zinc will be evaluated for association with taste and/or smell impairment
OTHER	Chronic rhinosinusitis	Chronic rhinosinusitis will be evaluated for association with smell impairment
OTHER	Dialysis adequacy	Dialysis adequacy will be evaluated for association with taste and/or smell impairment
OTHER	Decayed missing filled teeth index (DMFT)	DMFT will be evaluated for association with taste impairment

Timeline

• Start date: 2017-02-15
• Primary completion: 2017-04-01
• Completion: 2017-04-01
• First posted: 2017-02-03
• Last updated: 2017-06-26

Locations

1 site across 1 country: United States