NCT03041129

Post-Prandial Liver Glucose Metabolism in PCOS

Post-Prandial Liver Glucose Metabolism in Polycystic Ovarian Syndrome (PCOS) and Understanding Standard of Care Medications

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 19 (actual)
• Sponsor: University of Colorado, Denver · Academic / Other
• Sex: Female
• Age: 12 Years – 21 Years
• Healthy volunteers: Accepted

Summary

The Investigators will measure if hepatic metabolism is upregulated in obese girls with PCOS and hepatic steatosis (HS), compared to PCOS without HS and obese controls without HS.

Detailed description

This will be a cross-sectional study with 4 groups of youth. A 6 hour OSTT (Oral Sugar Tolerance Test) with an oral U-C13 glycerol tracer will be paired with nuclear magnetic resonance spectroscopy (NMR) isotopomer analysis of serum samples to describe flux through the hepatic pentose phosphate pathway, TCA cycle and FAS pathways in girls with PCOS receiving lifestyle only, metformin or oral contraceptive treatment, and obese girls with regular menses receiving lifestyle therapy. Hepatic steatosis will be measured with MRI. Please note that 3 study groups: PCOS on metformin, PCOS on oral contraceptive treatment, and obese girls with regular menses were not funded in the study, so no participants were enrolled in these 3 arms of the study.

Conditions

• Polycystic Ovarian Syndrome
• Obesity
• Hepatic Steatosis

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	oral glucose tolerance test	6 hours OGTT
DIAGNOSTIC_TEST	MRI of liver	MRI of the liver and use of DIXON method

Timeline

• Start date: 2017-04-14
• Primary completion: 2018-08-29
• Completion: 2018-09-29
• First posted: 2017-02-02
• Last updated: 2024-04-17
• Results posted: 2024-04-17

Locations

1 site across 1 country: United States