NCT03038464

Synovial Aspiration and Serological Testing in Two-stage Revision Arthroplasty of Prosthetic Joint Infection

Benefit of Synovial Aspiration and Serological Testing in Two-stage Revision Arthroplasty of Prosthetic Joint Infection

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 40 (estimated)
• Sponsor: Technical University of Munich · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Accepted

Summary

The two-stage protocol is gold standard in terms of infection control treating prosthetic joint infections of total hip and total knee arthroplasty. The antibiotic pause for diagnostic reasons before reconstruction (stage two) is discussed concerning persistence of infection and development of resistant bacterial strains. Serological markers and synovial analysis are common use to exclude persistence of infection. The investigators therefore asked 1) is the serological testing of c-reactive protein and leukocytes a valuable tool to predict a persistence of infection and 2) what is the role of synovial aspiration of PMMA Spacers on hip and knee joints.

Conditions

• Diagnosis Prosthetic Joint Infection

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Synovial biopsy	Biopsy of jint prior reimplantation of new joint prosthesis

Timeline

• Start date: 2016-11-01
• Primary completion: 2019-04-01
• Completion: 2019-05-01
• First posted: 2017-01-31
• Last updated: 2017-04-25

Locations

1 site across 1 country: Germany