NCT03036826

Computer-based Dosage Calculation for Antibiotics

Computer-basierte Dosierungsregime Von Antiinfektiva Bei eingeschränkter Nierenfunktion Und Kontinuierlichen Nierenersatztherapieverfahren (Computer-based Dosage Calculation for Antibiotics in Patients With Impaired Renal Function or Renal Replacement Therapy)

• Status: Withdrawn
• Phase: —
• Study type: Observational
• Enrollment: 0 (actual)
• Sponsor: University Hospital Tuebingen · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Adequate dosing of antiinfective therapy in critically ill patients with impaired or lost renal function or continuous renal replacement therapy is nearly impossible without measuring the drug concentration in blood samples. In many hospitals that is still not an option. The investigators aim to show, that computer based calculation can avoid over- or under-dosing.

Detailed description

Adequate dosing of antiinfective therapy in critically ill patients is most important to improve outcome. Patients with impaired or lost renal function or continuous renal replacement therapy are hard to calculate using drug information sheets or "lists" with recommendations. It is nearly impossible to avoid drug levels that are much to low or much to high without measuring the concentration in blood samples. Since that possibility is still not available in every clinic we aim to show, how a computer based calculation can help to find the adequate dosing.

Conditions

• Acute Kidney Insufficiency
• Anti-Infective Agent Toxicity

Interventions

Type	Name	Description
DRUG	Piperacillin/tazobactam	antiinfective therapy with Piperacillin/Tazobactam within routine care
DRUG	Meropenem	antiinfective therapy with Meropenem within routine care

Timeline

• Start date: 2019-06-01
• Primary completion: 2021-06-01
• Completion: 2021-12-01
• First posted: 2017-01-30
• Last updated: 2019-12-24

Locations

1 site across 1 country: Germany