NCT03036748

Increased Activity of ENaC in Proteinuric Kidney Transplant Recipients

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 14 (actual)
• Sponsor: University of Southern Denmark · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

The aim of this study is to determine if amiloride, a diuretic drug, is capable of increasing renal salt excretion, lowering blood pressure and inhibiting uPA in kidney transplant recipients with proteinuria compared to normoalbuminuric transplant patients.

Conditions

• Kidney Transplant; Complications

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Standardized sodium diet	Dietary Supplement: Standardized salt diet 150 mmol NaCl per day given as three meals daily for 5 consecutive days.
DRUG	Tbl amiloride	Drug: Amiloride Amiloride tablet 10 mg two times daily (morning and afternoon) for one day

Timeline

• Start date: 2017-01-01
• Primary completion: 2021-09-01
• Completion: 2021-09-01
• First posted: 2017-01-30
• Last updated: 2022-12-27

Locations

1 site across 1 country: Denmark