NCT03034733

The Effect of Dexamethasone on Pain After Total Knee Replacement Surgery

The Effect of Intravenous Single-dose Dexamethasone on Pain After Total Knee Replacement Surgery

• Status: Terminated
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 27 (actual)
• Sponsor: University of Oulu · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to examine, if a single-dose of dexamethasone given during the operation, alleviates pain after knee replacement surgery.

Detailed description

The purpose of this study is to examine, if a single-dose of dexamethasone given during the operation, alleviates pain after knee replacement surgery. This is also a dose-finding study comparing two doses of dexamethasone. Total knee arthroplasty causes considerable pain. Multimodal analgesia and peripheral nerve blocks are used for treatment of pain. Some studies suggest that glucocorticoids alleviate postoperative pain. The optimal dose of dexamethasone in treatment of postoperative pain is not known. Studies on this subject in patients with total knee replacement are sparse. Potential side-effects of dexamethasone (hyperglycemia, wound infection) need to be studied. Patients coming for primary knee replacement surgery are enrolled. The patients in each study group receive multimodal therapy for postoperative pain: etoricoxib, paracetamol, gabapentin and oxycodone. A single dose of intravenous dexamethasone (0,15 mg/kg or 0,25 mg/kg) or a placebo (saline) is administered to the patient during the operation. The effect of dexamethasone on postoperative pain is observed: main outcome is dynamic pain at 24 h postoperatively. The extent of inflammatory reaction is measured (CRP). Serial blood glucose measurements are done.

Conditions

• Arthroplasty, Knee Replacement
• Pain, Postoperative

Interventions

Type	Name	Description
DRUG	Dexamethasone	intravenous dexamethasone, two groups: 0,15 mg/kg, 0,25 mg/kg
DRUG	Sodium Chloride, (24)NaCl 0,9%	intravenous placebo

Timeline

• Start date: 2017-02-15
• Primary completion: 2018-01-31
• Completion: 2018-01-31
• First posted: 2017-01-27
• Last updated: 2018-11-29

Locations

1 site across 1 country: Finland