NCT03034096

General Anesthetics in CAncer REsection Surgery (GA-CARES) Trial

General Anesthetics in CAncer REsection Surgery (GA-CARES) Trial: Pragmatic Randomized Trial of Propofol vs Volatile Inhalational Anesthesia

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 1,826 (actual)
• Sponsor: Stony Brook University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This is a large pragmatic multicenter trial comparing maintenance of general anesthesia with total intravenous anesthesia using propofol versus volatile agent (sevoflurane, isoflurane, or desflurane) during cancer surgery. The primary endpoint is all-cause mortality.

Conditions

• Anesthesia, General
• Surgical Oncology

Interventions

Type	Name	Description
DRUG	Propofol	Maintenance of general anesthesia with propofol infusion
DRUG	Volatile Agent	Maintenance of general anesthesia with volatile agent (sevoflurane, desflurane, or isoflurane)

Timeline

• Start date: 2017-01-31
• Primary completion: 2024-09-30
• Completion: 2024-09-30
• First posted: 2017-01-27
• Last updated: 2025-05-04

Locations

5 sites across 1 country: United States

Regulatory

• FDA-regulated drug study