NCT03033277

Human Umbilical Cord Mesenchymal Stem Cells (HUC-MSCs) Transplantation in Women With Primary Ovarian Insufficiency (POI)

• Status: Unknown
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 320 (estimated)
• Sponsor: Chinese Academy of Sciences · Other Government
• Sex: Female
• Age: 20 Years – 40 Years
• Healthy volunteers: Not accepted

Summary

There is a high incidence of women suffering from Primary Ovarian Insufficiency (POI). One of the most common treatments for POI is hormone replacement therapy (HRT), but HRT doesn't work well, and it has been shown to increase the risk of blood clots in the veins, ovarian cancer, and breast cancer. The ability of MSCs to differentiate into oocyte-like cells has been previously documented. Herein the purpose of this work is to evaluate the therapeutic potential of cell therapy in women suffering from POI.

Conditions

• Primary Ovarian Insufficiency

Interventions

Type	Name	Description
BIOLOGICAL	Placebo transplantation	Intraovarian injection of placebo through vagina under the guidance of ultrasonic.
BIOLOGICAL	HUC-MSCs transplantation	Intraovarian injection of HUC-MSCs through vagina under the guidance of ultrasonic.

Timeline

• Start date: 2016-02-01
• Primary completion: 2017-04-01
• Completion: 2018-07-01
• First posted: 2017-01-26
• Last updated: 2017-01-26

Locations

1 site across 1 country: China