NCT03032640

Interactions of Human Gut Microbiota With Intestinal Sweet Taste Receptors

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 102 (actual)
• Sponsor: AdventHealth Translational Research Institute · Academic / Other
• Sex: All
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to collect data to examine whether short-term consumption of non-caloric artificial sweeteners (NCASs), such as saccharin, can lead to changes in blood sugar levels and in the composition of the bacteria in the large intestine.

Conditions

• Obesity

Interventions

Type	Name	Description
OTHER	Oral Glucose Tolerance Test (OGTT)	Once we test the fasting plasma glucose (after an overnight fast), subject will receive a 75g glucose beverage they will have to drink within 5 minutes. Then after drinking the beverage, 8 blood samples will be collected through the IV catheter, over the next 3 hours.
OTHER	Assessment of dietary compliance	Assessment of consumption of non-caloric artificial sweeteners
OTHER	Stool sampling	Subjects will provide a stool sample.
OTHER	Sodium Saccharin	Subjects in group 1 and group 3 will be provided with sodium saccharin.
OTHER	Placebo	Subjects in group 2 will be provided with placebo.
OTHER	Lactisole	Subjects in group 3 and group 4 will be provided with lactisole.

Timeline

• Start date: 2017-01-26
• Primary completion: 2018-03-21
• Completion: 2022-10-18
• First posted: 2017-01-26
• Last updated: 2023-02-02

Locations

1 site across 1 country: United States