NCT03029845

Propranolol for Treating Fibromyalgia Pain

Propranolol for Treating Fibromyalgia Pain: Pilot Study

• Status: Terminated
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 15 (actual)
• Sponsor: University of Utah · Academic / Other
• Sex: Female
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The purpose of the study to evaluate the feasibility of using low dose propranolol for people with fibromyalgia.

Detailed description

The main purpose of this study is to collect pilot feasibility study data for the use of low dose propranolol for helping treat fibromyalgia. The investigators plan to compare 20mg twice a day dosage of propranolol and 10mg twice a day dosage of propranolol to placebo. The design is a 3 arm, double blind randomized control trial. The investigators will also test ECG and respiratory assessment as a part of the safety screening and the feasible assessment of respiratory sinus arrhythmia. Propranolol is not indicated to treat pain. However, the previous studies showed that low dose propranolol can re-regulate the adrenergic dysfunction and reduce pain in people with chronic musculoskeletal pain. However, the investigators are not aiming to develop a new indication of the drug.

Conditions

• Fibromyalgia Pain

Interventions

Type	Name	Description
DRUG	Propranolol 1	Participants will take 20 mg propranolol twice a day for 2 weeks
DRUG	Propranolol 2	Participants will take 10 mg propranolol twice a day for 2 weeks
DRUG	Placebo	Participants will take placebo twice a day for 2 weeks

Timeline

• Start date: 2017-01-01
• Primary completion: 2018-04-01
• Completion: 2018-07-01
• First posted: 2017-01-24
• Last updated: 2018-08-23

Locations

1 site across 1 country: United States