NCT03021876

L-carnitine Corrects Ammonia Metabolism in Hepatectomized Patients

• Status: Unknown
• Phase: Phase 2 / Phase 3
• Study type: Interventional
• Enrollment: 80 (estimated)
• Sponsor: Kochi University · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

L-carnitine is synthesized from lysine and methionine. Postmortem concentrations of carnitine in liver, muscle, heart, kidney, and brain averaged only one-fourth to one-third those in corresponding tissues of eight normally nourished non-hepatic patients who died after an acute illness of a 1-3-day duration. In the recent years, it has been reported that sirtuin 3 (SIRT3) is protective against acute kidney injury (AKI) and suggest that enhancing SIRT3 to improve mitochondrial dynamics has potential as a strategy for improving outcomes of renal injury. In the current study, it is the first clinical interventional research whether L-carnitine corrects ammonia metabolism associated with liver injury in hepatectomized patients.

Conditions

• Ammonia Metabolism

Interventions

Type	Name	Description
DRUG	L-carnitine	treatment with oral L-carnitine, 1500 mg/body per day
OTHER	usual intake	baseliner

Timeline

• Start date: 2016-04-01
• Primary completion: 2018-04-01
• Completion: 2018-04-01
• First posted: 2017-01-16
• Last updated: 2017-01-16

Locations

1 site across 1 country: Japan