NCT03019835

Can we Antagonize Mivacurium With Neostigmine ?

Can we Antagonize Mivacurium With Neostigmine

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 80 (actual)
• Sponsor: Université Libre de Bruxelles · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

The antagonism of neuromuscular blocking agents (NMBA) (or curares), as well as the antagonism of other drugs used in anesthesia, is a major challenge for the speciality. Residual paralysis is indeed a risk factor for post-operative morbidity and mortality and antagonization of curares at the end of the procedure is associated with a reduction in mortality . Its use should be as large as possible and its contraindications are extremely rare. The antagonism of the NMBA reduces the duration of the neuromuscular block and the complications that are associated . In this study, the investigators use mivacurium (or Mivacron) as non-depolarizing curare and neostigmine as an antagonist. Neostigmine reduces the duration of the neuromuscular block induced by mivacurium, By reducing the breakdown of acetylcholine, neostigmine induces an increase in acetylcholine in the synaptic cleft which competes for the same binding site as nondepolarizing neuromuscular blocking agents, and reverses the neuromuscular blockade. But the use of neostigmine in current practice is not very widespread in this clinical situation. The reduction in the duration of the block is significant in comparison with a spontaneous recovery . Moreover, spontaneous recovery is not always complete and sometimes very long. Nevertheless, its action is effective and this study could support this use but also specify the duration and the quality of the return to normal of the neuromuscular transmission.

Conditions

• Mivacurium
• Neostigmine
• Residual Paralysis

Interventions

Type	Name	Description
DRUG	Neostigmine (40 mcg / kg) at different time of neuromuscular block's recovery
OTHER	Spontaneous recovery	just measuring the Train Of Four at 3 6 9 12 and 15 minutes and measure the Train Of Four Ratio

Timeline

• Start date: 2016-12-01
• Primary completion: 2017-04-22
• Completion: 2017-04-22
• First posted: 2017-01-13
• Last updated: 2017-05-19

Locations

1 site across 1 country: Belgium