Trials / Recruiting
RecruitingNCT03019757
Distinguishing Between Alzheimer's Disease, Lewy Body Dementia, and Parkinson's Disease
- Status
- Recruiting
- Phase
- —
- Study type
- Observational
- Enrollment
- 76 (estimated)
- Sponsor
- Douglas Scharre · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
The study is designed to characterize the clinical, neuropsychological, polysomnographic, and neuroimaging findings among subjects with Alzheimer's disease, Lewy Body dementia, and Parkinsons' Disease.
Detailed description
The study will use structural and functional MRIs, daTscans, fluorodeoxyglucose (FDG) PET scans, Amyvid PET scans, polysomnographs, neuropsychological testing, cerebrospinal fluid in willing participants to distinguish between a diagnosis of Alzheimer's disease, Lewy Body dementia, and Parkinson's Disease. All subjects will have a clinical evaluation, physical examination including vital signs and orthostatic blood pressures and pulses, neurological examination including UPDRS evaluation, genetic blood sample collection, neuropsychological testing, polysomnogram, and neuroimaging. The study partner will also be interviewed for completion of all of the behavioral and functional measures.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| RADIATION | DaTscan | A functional imaging of the dopamine transporter using the radioligand \[123I\]FP-CIT |
| RADIATION | F18-AV-45 | A brain scan to to measure the extent of amyloid deposition |
| RADIATION | FDG-PET | a brain scan measuring total and regional cerebral glucose metabolism wtih positron emission tomographs with 2-(18F) |
| GENETIC | APOE genotype | 10 ml of whole blood will be drawn and shipped to Athena Diagnostics for genetic testing. |
| PROCEDURE | Polysomnogram | Overnight sleep study |
| BEHAVIORAL | Clinical Assessment | Clinical assessments include cognitive, behavioral, and motor evaluations |
Timeline
- Start date
- 2018-08-30
- Primary completion
- 2026-12-01
- Completion
- 2026-12-01
- First posted
- 2017-01-13
- Last updated
- 2025-03-30
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT03019757. Inclusion in this directory is not an endorsement.