NCT03018808

Prevalence of Chronic Obstructive Pulmonary Disease (COPD) and Eosinophilia Among Primary Care Patients

A Cross-sectional Study to Characterize the Prevalence of COPD and Eosinophilia Among Primary Care Patients in Brazil

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 800 (actual)
• Sponsor: GlaxoSmithKline · Industry
• Sex: All
• Age: 35 Years
• Healthy volunteers: Not accepted

Summary

Early diagnosis and appropriate treatment for COPD subjects are both critical to minimize the progression of COPD and improve outcomes. Also, evidence suggests that high eosinophil (specific type of white blood cell that protects body against certain kinds of germs) level is associated with increased risk of both moderate and severe exacerbations in COPD subjects. To date, there is insufficient amount of data that describes the prevalence of COPD in Brazilian primary care units. Thus, this multicenter, cross-sectional study conducted in five centers located in five different Brazilian cities will provide estimation about the prevalence of COPD in primary care and will also determine the levels of eosinophils in subjects with confirmed COPD diagnosis. Approximately 2,500 eligible subjects are expected to be enrolled in the study.

Detailed description

The study is a cross sectional (prevalence study).

Conditions

• Pulmonary Disease, Chronic Obstructive

Interventions

Type	Name	Description
OTHER	Minimal questionnaire	The minimal questionnaire is a reduced version of the medical interview and it will include questions about sociodemographic information, previous diagnosis of COPD, co-morbidities and smoking habits.
OTHER	Medical interview	Medical interview includes medical history, sociodemographic and clinical information, including disease history, treatment history, smoking habits and use of biomass.
OTHER	CAT	The CAT is a questionnaire for COPD patients and is designed to measure the impact of COPD on a person's life over time.
PROCEDURE	Blood test	Blood samples will be collected at indicated time points
OTHER	anthropometric measures	Anthropologic measures will be performed.
OTHER	Oximetry	Digital pulse oximeter on the index finger after five minutes rest and before receiving bronchodilator for spirometry will be used to measure the pulse arterial oximetry. The average of three measurements at 10 second intervals will be recorded. The heart rate will be provided by the pulse oximeter.

Timeline

• Start date: 2019-06-03
• Primary completion: 2021-10-04
• Completion: 2021-10-04
• First posted: 2017-01-12
• Last updated: 2022-04-12

Locations

4 sites across 1 country: Brazil