NCT03018444

The Effect of HMG-CoA Reductase Inhibition on Postprandial GLP-1 Secretion

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 15 (actual)
• Sponsor: University Hospital, Gentofte, Copenhagen · Academic / Other
• Sex: Male
• Age: 18 Years – 70 Years
• Healthy volunteers: Accepted

Summary

The primary objective of the present study is to evaluate the effect of HMG-CoA reductase inhibition during 14 days on the postprandial plasma GLP-1 response in healthy individuals. Secondary objectives include the evaluation of HMG-CoA reductase inhibition on postprandial glucose tolerance, gallbladder emptying, gastric emptying, plasma responses of lipids, bile acids and pancreatic and enteric hormones known to influence glucose metabolism and appetite, and faecal content of bile acids and gut microbiota composition.

Conditions

• Diabetes Mellitus, Type 2
• Hydroxymethylglutaryl-CoA Reductase Inhibitors

Interventions

Type	Name	Description
DRUG	Atorvastatin	Atorvastatin tablet
OTHER	Placebo	Placebo tablet

Timeline

• Start date: 2016-10-01
• Primary completion: 2017-01-01
• Completion: 2017-01-01
• First posted: 2017-01-12
• Last updated: 2017-03-03

Locations

1 site across 1 country: Denmark