NCT03016182

Remote Ischemic Preconditioning on Pulmonary Injury in Cardic Surgery

Effect of Remote Ischemic Preconditioning on Pulmonary Injury in Cardic Surgery

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: Xuzhou Medical University · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

During cardiac surgery with cardiopulmonary bypass , pulmonary dysfunction remains to be a problem complicating the postoperative course of the patients.Remote ischemic preconditioning(RIPC) with transient upper limb ischemia/reperfusion is a novel, simple, cost-free,non-pharmacological and non-invasive strategy.Recent several trials suggested that RIPC could provide pulmonary protection by reducing serum biomarkers,however,whether the RIPC can improve the clinical outcomes in patients undergoing on-pump cardiac surgery,is still uncertain. The study hypothesis is: remote ischemic preconditioning will provide lung-protective effect and improve clinical outcomes in patients undergoing cardic surgery.

Detailed description

Remote ischemic preconditioning (RIPC) protocol will be induced during anesthesia by 3 cycles of 5-min upper limb ischemia and 5-min reperfusion using a blood pressure cuff inflated to a pressure 200mmHg

Conditions

• Lung Injury
• Remote Ischemic Preconditioning

Interventions

Type	Name	Description
PROCEDURE	Remote Ischemic Preconditioning	RIPC will be induced during anesthesia by 3 cycles of 5-min upper limb ischemia and 5-min reperfusion using a blood-pressure cuff inflated to a pressure 200mmHg
PROCEDURE	Control	Control group witnout remote ischemic preconditioning

Timeline

• Start date: 2017-02-07
• Primary completion: 2018-02-01
• Completion: 2018-02-01
• First posted: 2017-01-10
• Last updated: 2017-02-23

Locations

1 site across 1 country: China