Trials / Completed
CompletedNCT03010735
Effects of Probiotics on the Patients With End Stage Renal Disease (ESRD)
Effects of Probiotics on Metabolism of Uremic Toxin in Patients With End Stage Renal Disease (ESRD)
- Status
- Completed
- Phase
- Phase 2 / Phase 3
- Study type
- Interventional
- Enrollment
- 150 (actual)
- Sponsor
- China Agricultural University · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
The purpose of this study is to investigate the effects of oral administration of probiotics on the metabolism of uremic toxins, in the patients with End Stage Renal Disease (ESRD). One hundred and fifty hemodialysis patients are recruited, and a Double Blind Randomized Parallel Controlled Trial was performed.The microbiota-derived uremic toxin, such as indoxyl sulfate and p-cresol sulfate, are measured as Primary Outcome. The Fecal microbiome, fecal metabolites, blood metabolites, defecation, Gastrointestinal Symptoms The Kidney Disease Quality of Life and The Occurrence of Cardiovascular Event are also assessed.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DIETARY_SUPPLEMENT | probiotics | Daily take 4.0E+10 CFU of probiotics |
| DIETARY_SUPPLEMENT | Placebo |
Timeline
- Start date
- 2015-06-01
- Primary completion
- 2017-02-01
- Completion
- 2017-12-01
- First posted
- 2017-01-05
- Last updated
- 2020-10-22
Locations
3 sites across 1 country: China
Source: ClinicalTrials.gov record NCT03010735. Inclusion in this directory is not an endorsement.