NCT03006406

Effect of Shorten Gonadotropin-releasing Hormone Agonist Therapy on the Outcome of in Vitro Fertilization-Embryo Transfer in Patients With Endometriosis

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 50 (estimated)
• Sponsor: The First Affiliated Hospital of Zhengzhou University · Academic / Other
• Sex: Female
• Age: 22 Years – 42 Years
• Healthy volunteers: Not accepted

Summary

Gonadotropin-releasing hormone analogue (GnRH-a) is a synthetic decapeptide compound which can down-regulate pituitary function causing a temporary low estrogen state. Since endometriosis is an estrogen-dependent disease, the use of long-acting GnRH-a can control the growth of endometriosis by inhibiting ovary function.Some scholars have found that, for adenomyosis patients who received a super long protocol (pretreatment of long-acting GnRH-a for 1-2 months) in IVF treatment, the pregnancy outcome is comparable to that of the controls with normal uterus. Thus, the aim of this study is to compare the clinical pregnancy rate in patients treated with GnRH-a for 1, or 2 months.

Conditions

• Clinical Pregnancy Rate

Interventions

Type	Name	Description
DRUG	Long term GnRH-a (3.75mg)	patient in this group only receive GnRH-a 3.75 for pituitary down-regulation

Timeline

• Start date: 2016-01-01
• Primary completion: 2017-01-01
• Completion: 2018-01-01
• First posted: 2016-12-30
• Last updated: 2016-12-30

Locations

1 site across 1 country: China