NCT03003793

Insulin Sensitivity in Patients With Atopic Dermatitis

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 32 (actual)
• Sponsor: University Hospital, Gentofte, Copenhagen · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Accepted

Summary

The incidence of atopic dermatitis and type 2 diabetes, respectively, has increased over many years. Novel research shows an association between the two conditions. While this relationship at least in theory can be explained by lifestyle factors, there is reason to believe that other pathophysiological mechanisms are involved. Hence, our hypothesis is that patients with atopic dermatitis are insulin resistant due to their chronic inflammatory state. Insulin resistance might play an unknown part in the increased frequency of type 2 diabetes among patients with atopic dermatitis. In the present project, the investigators aim to measure insulin sensitivity by means of the 'golden standard' hyperinsulinaemic euglycaemic clamp in patients suffering from atopic dermatitis compared to a healthy control group (matched case-control study). The project is a close collaboration between The Department of Dermatology and Allergy and Center for Diabetes Research at Gentofte Hospital.

Conditions

• Atopic Dermatitis/Eczema
• Type 2 Diabetes

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Hyperinsulinemic euglycemic clamp	Hyperinsulinemic euglycemic clamp to detect insulin sensitivity

Timeline

• Start date: 2015-11-01
• Primary completion: 2016-09-01
• Completion: 2017-12-01
• First posted: 2016-12-28
• Last updated: 2019-10-18
• Results posted: 2019-10-18

Locations

1 site across 1 country: Denmark