Trials / Completed
CompletedNCT02996279
Chorioamnionitis and Proinflammatory S100A12
Impact of Chorioamnionitis on Maternal and Fetal Levels of Proinflammatory S100A12
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 69 (actual)
- Sponsor
- Catholic University of the Sacred Heart · Academic / Other
- Sex
- All
- Age
- —
- Healthy volunteers
- Not accepted
Summary
Histologic chorioamnionitis (HCA) may lead to the fetal inflammatory response syndrome (FIRS) and increased levels of proinflammatory molecules.
Detailed description
Histologic chorioamnionitis (HCA) may lead to the fetal inflammatory response syndrome (FIRS). The aim of this pilot study was to evaluate S100A12, a marker of innate immune activation, in mothers with or without HCA and in their infants. Concentrations of S100A12, Interleukin 6 (IL-6) and C-reactive protein (CRP) were evaluated in maternal, cord, and neonatal blood of very preterm infants. Histologic examinations of placentae and umbilical cords were performed.
Conditions
Timeline
- Start date
- 2012-02-01
- Primary completion
- 2013-02-01
- Completion
- 2013-03-01
- First posted
- 2016-12-19
- Last updated
- 2016-12-19
Source: ClinicalTrials.gov record NCT02996279. Inclusion in this directory is not an endorsement.