NCT02993718

Sedation by Dexmedetomidine and Propofol

Comparison of the Upper Airway Patency by Dexmedetomidine and Propofol Used for Sedation

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 52 (actual)
• Sponsor: Seoul National University Bundang Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

Under the hypothesis that dexmedetomidine sedation would result in less upper airway obstruction, we evaluated the occurrence of upper airway collapse or the requirement of airway intervention in patients with obstructive sleep apnea during dexmedetomidine or propofol sedation.

Conditions

• Anesthesia, Spinal

Interventions

Type	Name	Description
DRUG	Dexmedetomidine	As a loading dose, 0.5 μg/kg dexmedetomidine was administered over 10 min, which was then administered continuously at a dose of 0.2-0.8 μg/kg/h. Sedation was maintained at modified observer's assessment of alertness/sedation scale 3
DRUG	Propofol	Propofol was infused continuously via a target-controlled infusion device, and the effect-site concentration was maintained with a range of 0.5-2.0 μg/ml. Sedation was maintained at modified observer's assessment of alertness/sedation scale 3

Timeline

• Start date: 2015-01-01
• Primary completion: 2017-06-01
• Completion: 2017-06-01
• First posted: 2016-12-15
• Last updated: 2017-09-14

Locations

1 site across 1 country: South Korea