NCT02992691

Efficacy of Three Experimental Toothpastes to Remove Plaque

Dose Response of Three Experimental Dentifrices in Plaque Removal in a Single Brushing Model

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 75 (actual)
• Sponsor: GlaxoSmithKline · Industry
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

The Dose response of three experimental toothpastes (test product 1, test product 2 and test product 3) to remove plaque after a single brushing, compared to a positive control and negative control dentifrice will be evaluated.

Detailed description

This will be a single centre, controlled, examiner blind, five treatment, five period, crossover design study in healthy participants. This study will evaluate the dose response of three experimental toothpastes (test product 1, test product 2 and test product 3) to remove plaque after a single brushing, compared to a positive control and negative control dentifrice. Plaque removal efficacy will be measured by Turesky modification of Quigley Hein Plaque Index (TPI).

Conditions

• Dental Plaque

Interventions

Type	Name	Description
DRUG	20% w/w sodium bicarbonate	Dentifrice containing 20% w/w sodium bicarbonate.
DRUG	35% w/w sodium bicarbonate	Dentifrice containing 35% w/w sodium bicarbonate.
DRUG	50% w/w sodium bicarbonate	Dentifrice containing 20% w/w sodium bicarbonate.
DRUG	67% w/w sodium bicarbonate	Dentifrice containing 67% w/w sodium bicarbonate.
DRUG	0% w/w sodium bicarbonate	Dentifrice containing 0% sodium bicarbonate and 1450 parts per million (ppm) fluoride.

Timeline

• Start date: 2016-12-19
• Primary completion: 2017-02-02
• Completion: 2017-02-02
• First posted: 2016-12-14
• Last updated: 2019-05-29
• Results posted: 2018-10-29

Locations

1 site across 1 country: Germany