NCT02992639

Weight Loss Effect on Circulating Liver Enzymes

Weight Loss Effect on Circulating Levels of Liver Enzymes in Overweight Subjects With High Visceral Fat Area: 12-week Randomized Controlled Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 80 (actual)
• Sponsor: Yonsei University · Academic / Other
• Sex: All
• Age: 20 Years – 60 Years
• Healthy volunteers: Accepted

Summary

To investigate weight loss effect with mild calorie restriction on circulating levels of liver enzymes in nondiabetic and overweight subjects with high visceral fat area \[visceral fat area (VFA) at L4 ≥ 100 cm²\].

Detailed description

A 12-week randomized, placebo-controlled study was conducted on 80 nondiabetic and overweight subjects with high VFA. The participants divided into two groups: 12-week mild calorie restriction (a 300 kcal/day intake reduction, n=40) or no treatment (control, n=40). The randomization was according to computer-generated block randomization (placebo:test = 1:1). Before and after intervention period, venous blood samples were obtained from the subjects, and biochemical parameters including circulating liver enzymes were measured.

Conditions

• Visceral Fat
• Liver Dysfunction

Interventions

Type	Name	Description
BEHAVIORAL	Control group	The participants who included in control group did not receive any treatment.
BEHAVIORAL	Weight loss group	The participants who included in weight loss group followed a 12-week weight loss program consisting of a 300 kcal/day reduction of thier usual caloric intakes

Timeline

• Start date: 2015-06-01
• Primary completion: 2016-10-01
• Completion: 2016-10-01
• First posted: 2016-12-14
• Last updated: 2017-02-15

Locations

1 site across 1 country: South Korea