NCT02991339

The Effects of Dexamethasone Administration on Jaundice Following Liver Resection

The Effects of Dexamethasone Administration on Jaundice Following Liver Resection: a Randomized Controlled Trial

• Status: Completed
• Phase: Phase 2 / Phase 3
• Study type: Interventional
• Enrollment: 76 (actual)
• Sponsor: Shanghai Zhongshan Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

The investigators were aiming to evaluate whether dexamethasone administration accelerates the recovery from hepatectomy-related jaundice and decreases the rates of post-hepatectomy liver failure and its safety in the subjects who developed elevated serum total bilirubin.

Detailed description

Post-operative jaundice is one of the most common complications after hepatectomy for various liver tumors. Glucocorticoids, including dexamethasone, prednisolone, and methylprednisolone, were widely used to treat jaundice in the patients with severe hepatitis, liver dysfunction or liver failure. It was reported that glucocorticoids decrease the rates of liver dysfunction or mortality in those patients. However, whether post-operative glucocorticoids administration alleviated jaundice or deceased the rates of post-hepatectomy liver failure (PLF) yet to be determined. In this study, the investigators were aiming to evaluate whether dexamethasone administration accelerates the recovery from hepatectomy-related jaundice and decreases the rates of PLF and its safety in the subjects who developed elevated serum TB.

Conditions

• Liver Dysfunction
• Hepatectomy
• Bilirubinaemia
• Jaundice

Interventions

Type	Name	Description
DRUG	Dexamethasone	Dexamethasone 10 mg iv for 2 days; then 5 mg iv for 1 day

Timeline

• Start date: 2016-06-01
• Primary completion: 2017-12-01
• Completion: 2018-07-01
• First posted: 2016-12-13
• Last updated: 2021-06-10

Locations

1 site across 1 country: China