NCT02988908

Memory and Mental Health in Aging

Memory and Mental Health in Aging: Psychopharmacological Augmentation of Memory Training in Older Adults

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 198 (actual)
• Sponsor: Stanford University · Academic / Other
• Sex: All
• Age: 55 Years – 90 Years
• Healthy volunteers: Accepted

Summary

A comparison of memory training with and without donepezil.

Detailed description

Study 1: Investigators evaluated the short-term and longer-term efficacy and effectiveness of a pharmacologic augmentation strategy for a nonpharmacologic treatment to improve memory performance in nondemented older adults. Investigators used a randomized controlled trial with parallel groups design that compares two Treatments: DONEPEZIL + COGNITIVE TRAINING versus PLACEBO + COGNITIVE TRAINING. Study 2: The second study looked more closely at dosage. Investigators hoped to determine the best dosage of the drug donepezil for enhancing the effects of the memory training program.

Conditions

• Memory

Interventions

Type	Name	Description
DRUG	Donepezil	Participants received donepezil as 5mg pills per day for 6 weeks, then 10 mg per day for the remainder of the 52-week trial. Participants also received 2 weeks of memory training at weeks 13-14
DRUG	Placebos	Participants received placebo as 5mg pills per day for 6 weeks, then 10 mg per day for the remainder of the 52-week trial. Participants also received 2 weeks of memory training at weeks 13-14

Timeline

• Start date: 2000-04-01
• Primary completion: 2007-09-01
• Completion: 2007-09-01
• First posted: 2016-12-09
• Last updated: 2017-02-10

Locations

1 site across 1 country: United States